Planaria resa sjsu

We have begun to examine the pattern of expression of these genes in the animal; the on-going expression screen has revealed more than one hundred genes expressed in the CNS, regenerating tissue or the stem cell population. Thus, planarians are excellent models in which to investigate fundamental mechanisms regulating stem cells. During the reporting period, we identified neural-specific transcription factor belonging to the basic Helix-Loop-Helix bHLH gene family. Forty years ago, studies on the mammalian brain provided evidence that new neurons are generated throughout life. To identify genes that are differentially expressed during regeneration of the CNS, we completed high-throughput gene expression studies microarray and RNA-seq using samples obtained from tissue replaced in the early phases of regeneration of the planarian head after amputation. We are currently performing extended knockdown experiments for 42 of the genes. Studies of organisms that can regenerate the CNS have excellent potential to improve our understanding of how adult stem cells can be harnessed for therapeutic purposes. We were specifically interested in understanding how the remarkable ability of these animals to regenerate the central nervous system after injury or amputation.

California's Stem Cell Agency

Joint Mathematics Meetings January 4 7 (Wednesday Saturday),

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Ali Reza People San Jose State University

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Department of Accounting and Finance · College of Business · San José State University One Washington Square San José, CA Ali Reza of San Jose State University, CA (SJSU) | Read 2 publications, and contact Ali Reza on ResearchGate, the professional network for scientists. of Sigma Xi and RESA, make possible this direct form of meeting the . San Jose State College, "Develop. planaria (Dugesia) of certain growth compounds .
Thus, we are capitalizing on the molecular tools available to study planarian regeneration to identify and functionally characterize genes with critical roles in the repair of the CNS.

During the reporting period, we identified neural-specific transcription factor belonging to the basic Helix-Loop-Helix bHLH gene family. Successful identification of genes with no known or emerging roles in stem cell regulation would help to improve our knowledge of biological mechanisms regulating proliferation and differentiation of stem cells in the CNS.

Project Objective:.

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Results from these experiments have revealed interesting conserved genes with potential roles in stem cell regulation.

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Our understanding of how repair of the nervous system can be achieved could benefit from studies of organisms that, in contrast to humans, are capable of regenerating the nervous system. View Report The aim of our work is to use freshwater planarians non-parasitic flatworms as model organisms to understand how stem cells replace lost neurons after injury. All of these prospects will require that we fully understand how stem cells can be signaled to divide, acquire the desired cell fate and integrate into a functional nervous system. California's Stem Cell Agency Finally, based on their pattern of expression, we have targeted genes for studies aimed at characterizing their function during regeneration. We also found that COE is important for stem cell homeostasis, suggesting that studies using planarians could provide insights into how COE dysfunction leads to CNS diseases such as cancer. We also performed experiments to label cells replicating their DNA cycling cells followed by in situ hybridization and found we can readily detect cycling cells expressing neural-specific genes.

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Minor: Biochemistry Thesis: Inhibition of Planarian Regeneration BLATTNER, Brigham Young University, M.A. Degree, San Jose State College, Which Affect Perception in Ambiguous Situations GHANNAD, REZA / Tehran.

Joint Mathematics Meetings January 4 7 (Wednesday Saturday),

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Using genomic techniques, we examined gene expression changes following inhibition of COE expression and uncovered conserved genes required for CNS regeneration. To identify genes that are differentially expressed during regeneration of the CNS, we completed high-throughput gene expression studies using samples obtained from tissue replaced in the early phases of regeneration of the planarian head after amputation.

Grant Number:. Adult planarians possess a population of pluripotent stem cells, which serve to replace cells lost after wounding or during normal physiological turnover. In addition, we have examined in detail the function of the transcription factor COE. During the reporting period, we have successfully generated reagents that recognize planarian proteins.

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Planaria resa sjsu

We have capitalized on the molecular tools available to study planarian regeneration to identify and functionally characterize genes with critical roles in nervous system repair, patterning and function. Results from these experiments have revealed interesting conserved genes with potential roles in stem cell regulation. This information has the potential to contribute to our ability to induce human embryonic or adult stem cells to divide and acquire neuronal fates, which would be valuable for transplantation therapies to treat nervous system injuries or neurodegenerative disorders. Adult planarians possess a population of pluripotent stem cells, which serve to replace cells lost after wounding or during normal physiological turnover. The inability to recover from loss of neuronal function afflicts a large number of people: in the U. Isolation of cell fractions is underway and we anticipate the generation of these reagents to be completed this year. To develop tools and use planarians as a model for identifying factors that contribute to neural differentiation as it relates to regeneration, tissue homeostasis and stem cell biology.

(San Jose State College) will preside.

The amateur ing in planarians,James V. McConnell and George J. Joint Sigma Xi-RESA Luncheon.

Joint Annual. To develop tools and use planarians as a model for identifying factors that contribute to neural differentiation as it relates to regeneration, tissue homeostasis. tissue distribution and activities of neoblasts (planarian stem cells) in tissue dispersed Tree.

Ali Reza People San Jose State University

Danielle Perryman, San Jose State University.
For more than a century, scientists have been intrigued by freshwater planarians flatworms ; these animals, when cut into small pieces, have the remarkable ability to regenerate complete organisms from small body pieces. Ricardo Zayas.

During the reporting period, we identified neural-specific transcription factor belonging to the basic Helix-Loop-Helix bHLH gene family.

We are currently characterizing these markers and will use them, in combination with staining of proliferating cells, to analyze the transition of stem cells to specific neuronal cell types.

Using genomic techniques, we examined gene expression changes following inhibition of COE expression and uncovered conserved genes required for CNS regeneration.

In this study, we will use planarians to identify and analyze the function of genes implicated in neurogenesis during regeneration and normal cell turnover. Our research on planarian stem cells and neural regeneration has the potential to make contributions to our knowledge of genetic pathways that control neuronal determination of stem cells or, if disrupted, could lead to neurological disorders.

Planaria resa sjsu

Award Value:. This ability to regenerate missing parts originates from a population of adult stem cells planarians maintain throughout life. Careers at RESA RESA Power We were specifically interested in understanding how the remarkable ability of these animals to regenerate the central nervous system after injury or amputation. We capitalized on the molecular tools available to study planarian regeneration to identify and functionally characterize genes with key roles in nervous system repair, patterning and function. PubMed: Dev Dyn A Lissencephaly-1 homologue is essential for mitotic progression in the planarian Schmidtea mediterranea.